Menu

EMILIN-1 (Elastin Microfibril Interface Located Protein 1): Structural Support, Cellular Signalling, and Implications in Cardiovascular Health

Endocrinology Diagnostics

Basic Structure and Role

  • Glycoprotein essential for extracellular matrix formation
  • Present in elastic tissues like blood vessels and skin
  • Contains C-terminal region and EMI domain
  • Helps maintain tissue structural integrity and elasticity

Extracellular Matrix Functions

  • Organizes microfibers that anchor elastin
  • Maintains flexibility in frequently stretched tissues
  • Helps tissues withstand mechanical strain
  • Bridges structural support with cellular activities

Cardiovascular Impact

  • Regulates blood pressure levels
  • Inhibits TGF-β pathway to prevent fibrosis
  • Maintains blood vessel elasticity
  • Deficiency linked to increased atherosclerosis risk

Cellular Signaling Role

  • Interacts with integrin α4β1 for cell attachment
  • Regulates inflammation responses
  • Controls cell migration and adhesion
  • Helps protect against tissue damage

Therapeutic Potential

  • Target for treating fibrotic conditions
  • Could help prevent blood vessel stiffening
  • Shows promise for inflammatory disease treatment
  • Research ongoing for molecule development
  • Potential applications in cardiovascular and respiratory diseases
ENQUIRY FORM

More News

  • TNF Alpha: A Central Mediator of Inflammation and Immune Response

  • Sclerostin (SOST): The Master Regulator of Bone Formation

  • TNFSF11/RANKL: A Key Regulator of Bone Metabolism and Beyond

  • Superoxide Dismutase (SOD): The Body's Powerful Antioxidant Defence System