Cellular Fibronectin: A Key Orchestrator of Tissue Architecture and Wound Healing
Endocrinology Diagnostics
Structure and Composition
- Complex glycoprotein with dimeric/multimeric structure
- Contains three repeating units: Type I, II, and III modules
- Features unique EDA and EDB domains through alternative splicing
Synthesis and Secretion
- Locally produced by fibroblasts and endothelial cells
- Undergoes post-translational modifications in reticulum
- Can either attach to cell membrane or integrate into ECM
Cell Adhesion and Migration Functions
- RGD sequence in Type III module interacts with integrin receptors
- Engages with α5β1 and αvβ3 integrins
- Controls cell attachment, spreading, and movement
Developmental and Disease Roles
- Essential for embryonic development
- Critical for wound healing in adult tissues
- Abnormal levels linked to cancer progression
- Excessive buildup associated with organ fibrosis
Therapeutic Applications
- Research focuses on modulating cFN levels
- EDA region inhibition shows promise for cancer/fibrosis treatment
- Engineered cFN fragments being developed for wound healing
- Targeted approaches aim to minimize side effects
Suitable ELISA Kits
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